Highways:
Interstate 90 runs right through the heart of Spokane. It is the northernmost east-to-west, coast-to-coast interstate. Other two- to four-lane highways include US-195 from Lewiston, ID to Spokane, US-395 from the Canadian border to Spokane, US-2 from Everett, WA through Spokane to Newport, WA, and US-95 spanning from Canada to Mexico.

Spokane is also home to the brand new North Spokane Corridor, which had a preliminary opening on August 22, 2009. The highway will be a major corridor for freight transportation between Spokane and Canada. The highway connects to both U.S. Highway 2 and U.S. Highway 395.

Railways:
The two rail services in Spokane are Burlington Northern Santa Fe and Union Pacific/Southern Pacific. Both rail services ship nationally out of the switching yard located in Spokane Valley. BNSF ships daily while Union Pacific/Southern Pacific ships weekly. With its main office located in Spokane, BNSF strives to create, implement, and execute high-value logistics solutions for customers.

Prior to Expo '74, Spokane was a hub for railway transportation. Spokane was a stop along the Great Northern Railway in the late 1800's up until 1970, when the Burlingotn Northern Railroad was formed after a merger between four railways, including the Great Northern Railway.